diff --git a/docs/integrations/litestar.rst b/docs/integrations/litestar.rst
index 31f858a6f..0a5880754 100644
--- a/docs/integrations/litestar.rst
+++ b/docs/integrations/litestar.rst
@@ -126,3 +126,22 @@ or with class-based handler:
             async with container() as request_container:
                 b = await request_container.get(B)  # object with Scope.REQUEST
             return {"key": "value"}
+
+
+Guards
+******
+
+For ``Guard`` functions (which receive ``ASGIConnection`` instead of ``Request``), use the ``@inject_asgi`` decorator:
+
+.. code-block:: python
+
+    from litestar import ASGIConnection, BaseRouteHandler
+    from dishka.integrations.litestar import FromDishka, inject_asgi
+
+    @inject_asgi
+    async def my_guard(
+        connection: ASGIConnection,
+        _: BaseRouteHandler,
+        config: FromDishka[Config],
+    ) -> None:
+        ...
diff --git a/src/dishka/integrations/litestar.py b/src/dishka/integrations/litestar.py
index 573c78611..eddea3306 100644
--- a/src/dishka/integrations/litestar.py
+++ b/src/dishka/integrations/litestar.py
@@ -3,6 +3,7 @@
     "FromDishka",
     "LitestarProvider",
     "inject",
+    "inject_asgi",
     "inject_websocket",
     "setup_dishka",
 ]
@@ -10,9 +11,10 @@
 from collections.abc import Callable
 from functools import wraps
 from inspect import Parameter
-from typing import ParamSpec, TypeVar, get_type_hints
+from typing import Any, ParamSpec, TypeVar, get_type_hints
 
 from litestar import Controller, Litestar, Request, Router, WebSocket
+from litestar.connection import ASGIConnection
 from litestar.enums import ScopeType
 from litestar.handlers import (
     BaseRouteHandler,
@@ -34,6 +36,7 @@
 from dishka import Scope as DIScope
 from dishka.integrations.base import wrap_injection
 
+GuardDependencyT = TypeVar("GuardDependencyT")
 P = ParamSpec("P")
 T = TypeVar("T")
 
@@ -42,14 +45,20 @@ def inject(func: Callable[P, T]) -> Callable[P, T]:
     return _inject_wrapper(func, "request", Request)
 
 
+def inject_asgi(
+    func: Callable[[ASGIConnection, BaseRouteHandler, GuardDependencyT], T],
+) -> Callable[[ASGIConnection, BaseRouteHandler], T]:
+    return _inject_wrapper(func, "connection", ASGIConnection)  # type: ignore[invalid-return-type]
+
+
 def inject_websocket(func: Callable[P, T]) -> Callable[P, T]:
     return _inject_wrapper(func, "socket", WebSocket)
 
 
 def _inject_wrapper(
-        func: Callable[P, T],
-        param_name: str,
-        param_annotation: type[Request | WebSocket],
+    func: Callable[P, T],
+    param_name: str,
+    param_annotation: type[Request | WebSocket | ASGIConnection],
 ) -> Callable[P, T]:
     hints = get_type_hints(func)
 
@@ -61,17 +70,31 @@ def _inject_wrapper(
     if request_param:
         additional_params = []
     else:
-        additional_params = [Parameter(
-            name=param_name,
-            annotation=param_annotation,
-            kind=Parameter.KEYWORD_ONLY,
-        )]
+        additional_params = [
+            Parameter(
+                name=param_name,
+                annotation=param_annotation,
+                kind=Parameter.KEYWORD_ONLY,
+            ),
+        ]
+
+    if param_name == "connection":
+        def container_getter(
+            args: tuple[ASGIConnection], _: Any,
+        ) -> AsyncContainer:
+            return args[0].state.dishka_container
+    else:
+        def container_getter(
+            _: Any,
+            kwargs: dict[str, Request | WebSocket],
+        ) -> AsyncContainer:
+            return kwargs[param_name].state.dishka_container
 
     return wrap_injection(
         func=func,
         is_async=True,
         additional_params=additional_params,
-        container_getter=lambda _, r: r[param_name].state.dishka_container,
+        container_getter=container_getter,
     )
 
 
@@ -153,7 +176,8 @@ async def middleware(scope: Scope, receive: Receive, send: Send) -> None:
             di_scope = DIScope.SESSION
 
         async with request.app.state.dishka_container(
-            context, scope=di_scope,
+            context,
+            scope=di_scope,
         ) as request_container:
             request.state.dishka_container = request_container
             await app(scope, receive, send)
diff --git a/tests/integrations/litestar/test_litestar_guards.py b/tests/integrations/litestar/test_litestar_guards.py
new file mode 100644
index 000000000..42724e115
--- /dev/null
+++ b/tests/integrations/litestar/test_litestar_guards.py
@@ -0,0 +1,83 @@
+from collections.abc import AsyncGenerator
+from contextlib import asynccontextmanager
+from unittest.mock import Mock
+
+import pytest
+from asgi_lifespan import LifespanManager
+from litestar import Litestar, get
+from litestar.connection import ASGIConnection
+from litestar.handlers import BaseRouteHandler
+from litestar.testing import TestClient
+from litestar.types import Guard
+
+from dishka import make_async_container
+from dishka.integrations.litestar import (
+    DishkaRouter,
+    FromDishka,
+    inject_asgi,
+    setup_dishka,
+)
+from ..common import (
+    APP_DEP_VALUE,
+    AppDep,
+    AppProvider,
+)
+
+
+@asynccontextmanager
+async def dishka_app(
+    guard: Guard, provider: AppProvider) -> AsyncGenerator[TestClient, None]:
+    @get("/", guards=[guard])
+    async def endpoint() -> dict:
+        return {"status": "ok"}
+
+    app = Litestar([endpoint], debug=True)
+    container = make_async_container(provider)
+    setup_dishka(container, app)
+    async with LifespanManager(app):
+        yield TestClient(app)
+    await container.close()
+
+
+@asynccontextmanager
+async def dishka_auto_app(
+    guard: Guard, provider: AppProvider) -> AsyncGenerator[TestClient, None]:
+    @get("/")
+    async def endpoint() -> dict:
+        return {"status": "ok"}
+
+    router = DishkaRouter("", route_handlers=[endpoint], guards=[guard])
+    app = Litestar([router], debug=True)
+    container = make_async_container(provider)
+    setup_dishka(container, app)
+    async with LifespanManager(app):
+        yield TestClient(app)
+    await container.close()
+
+
+@inject_asgi
+async def guard_with_app(
+    connection: ASGIConnection,
+    _: BaseRouteHandler,
+    a: FromDishka[AppDep],
+    mock: FromDishka[Mock],
+) -> None:
+    mock(a)
+
+
+@pytest.mark.asyncio
+@pytest.mark.parametrize(
+    ("app_factory", "guard"),
+    [
+        (dishka_app, guard_with_app),
+    ],
+)
+async def test_guard_injects_app_dependency(
+    app_factory,
+    guard,
+    app_provider: AppProvider,
+):
+    async with app_factory(guard, app_provider) as client:
+        response = client.get("/")
+        assert response.status_code == 200
+        app_provider.mock.assert_called_with(APP_DEP_VALUE)