diff --git a/python/packages/autogen-ext/src/autogen_ext/models/anthropic/__init__.py b/python/packages/autogen-ext/src/autogen_ext/models/anthropic/__init__.py
index f31e7b1c0b72..cdc41ab751d2 100644
--- a/python/packages/autogen-ext/src/autogen_ext/models/anthropic/__init__.py
+++ b/python/packages/autogen-ext/src/autogen_ext/models/anthropic/__init__.py
@@ -1,8 +1,3 @@
-from ._anthropic_client import (
-    AnthropicBedrockChatCompletionClient,
-    AnthropicChatCompletionClient,
-    BaseAnthropicChatCompletionClient,
-)
 from .config import (
     AnthropicBedrockClientConfiguration,
     AnthropicBedrockClientConfigurationConfigModel,
@@ -12,6 +7,21 @@
     CreateArgumentsConfigModel,
 )
 
+try:
+    from ._anthropic_client import (
+        AnthropicBedrockChatCompletionClient,
+        AnthropicChatCompletionClient,
+        BaseAnthropicChatCompletionClient,
+    )
+except ImportError as e:  # pragma: no cover - only triggered when optional deps are missing
+    raise ImportError(
+        "Failed to import Anthropic dependencies required for AnthropicChatCompletionClient "
+        "and AnthropicBedrockChatCompletionClient.\n"
+        f"Original error: {e}\n"
+        "Required packages (installed via the 'anthropic' extra):\n"
+        '  pip install "autogen-ext[anthropic]"'
+    ) from e
+
 __all__ = [
     "AnthropicChatCompletionClient",
     "AnthropicBedrockChatCompletionClient",
diff --git a/python/packages/autogen-ext/src/autogen_ext/models/azure/__init__.py b/python/packages/autogen-ext/src/autogen_ext/models/azure/__init__.py
index 2dc7b9c70a98..cf015c969685 100644
--- a/python/packages/autogen-ext/src/autogen_ext/models/azure/__init__.py
+++ b/python/packages/autogen-ext/src/autogen_ext/models/azure/__init__.py
@@ -1,4 +1,12 @@
-from ._azure_ai_client import AzureAIChatCompletionClient
-from .config import AzureAIChatCompletionClientConfig
+try:
+    from ._azure_ai_client import AzureAIChatCompletionClient
+    from .config import AzureAIChatCompletionClientConfig
+except ImportError as e:  # pragma: no cover - only triggered when optional deps are missing
+    raise ImportError(
+        "Failed to import Azure AI dependencies required for AzureAIChatCompletionClient.\n"
+        f"Original error: {e}\n"
+        "Required packages (installed via the 'azure' extra):\n"
+        '  pip install "autogen-ext[azure]"'
+    ) from e
 
 __all__ = ["AzureAIChatCompletionClient", "AzureAIChatCompletionClientConfig"]
diff --git a/python/packages/autogen-ext/src/autogen_ext/models/openai/__init__.py b/python/packages/autogen-ext/src/autogen_ext/models/openai/__init__.py
index 2241f663af26..d3638dd2ad06 100644
--- a/python/packages/autogen-ext/src/autogen_ext/models/openai/__init__.py
+++ b/python/packages/autogen-ext/src/autogen_ext/models/openai/__init__.py
@@ -1,10 +1,21 @@
 from . import _message_transform
-from ._openai_client import (
-    AZURE_OPENAI_USER_AGENT,
-    AzureOpenAIChatCompletionClient,
-    BaseOpenAIChatCompletionClient,
-    OpenAIChatCompletionClient,
-)
+
+try:
+    from ._openai_client import (
+        AZURE_OPENAI_USER_AGENT,
+        AzureOpenAIChatCompletionClient,
+        BaseOpenAIChatCompletionClient,
+        OpenAIChatCompletionClient,
+    )
+except ImportError as e:  # pragma: no cover - only triggered when optional deps are missing
+    raise ImportError(
+        "Failed to import OpenAI dependencies required for OpenAIChatCompletionClient "
+        "and AzureOpenAIChatCompletionClient.\n"
+        f"Original error: {e}\n"
+        "Required packages (installed via the 'openai' extra):\n"
+        '  pip install "autogen-ext[openai]"'
+    ) from e
+
 from .config import (
     AzureOpenAIClientConfigurationConfigModel,
     BaseOpenAIClientConfigurationConfigModel,