diff --git a/packages/@react-aria/selection/src/useSelectableCollection.ts b/packages/@react-aria/selection/src/useSelectableCollection.ts
index 8646efb427c..85db6ee5cdc 100644
--- a/packages/@react-aria/selection/src/useSelectableCollection.ts
+++ b/packages/@react-aria/selection/src/useSelectableCollection.ts
@@ -10,7 +10,7 @@
  * governing permissions and limitations under the License.
  */
 
-import {CLEAR_FOCUS_EVENT, FOCUS_EVENT, focusWithoutScrolling, getActiveElement, getEventTarget, isCtrlKeyPressed, isFocusWithin, isTabbable, mergeProps, nodeContains, scrollIntoView, scrollIntoViewport, useEvent, useRouter, useUpdateLayoutEffect} from '@react-aria/utils';
+import {CLEAR_FOCUS_EVENT, FOCUS_EVENT, focusWithoutScrolling, getActiveElement, getEventTarget, isAppleDevice, isCtrlKeyPressed, isFocusWithin, isTabbable, mergeProps, nodeContains, scrollIntoView, scrollIntoViewport, useEvent, useRouter, useUpdateLayoutEffect} from '@react-aria/utils';
 import {dispatchVirtualFocus, getFocusableTreeWalker, moveVirtualFocus} from '@react-aria/focus';
 import {DOMAttributes, FocusableElement, FocusStrategy, Key, KeyboardDelegate, RefObject} from '@react-types/shared';
 import {flushSync} from 'react-dom';
@@ -137,7 +137,14 @@ export function useSelectableCollection(options: AriaSelectableCollectionOptions
       return;
     }
 
+    // uses shiftKey if selection mode is multiple
+    // if it's an apple device uses ctrlKey otherwise altKey
     const navigateToKey = (key: Key | undefined, childFocus?: FocusStrategy) => {
+      let shouldIgnoreModifierKeys = e.metaKey || (e.shiftKey && manager.selectionMode !== 'multiple') || (!isAppleDevice() ? e.altKey : e.ctrlKey);
+      if (shouldIgnoreModifierKeys) {
+        return;
+      }
+
       if (key != null) {
         if (manager.isLink(key) && linkBehavior === 'selection' && selectOnFocus && !isNonContiguousSelectionModifier(e)) {
           // Set focused key and re-render synchronously to bring item into view if needed.
@@ -148,6 +155,7 @@ export function useSelectableCollection(options: AriaSelectableCollectionOptions
           let item = getItemElement(ref, key);
           let itemProps = manager.getItemProps(key);
           if (item) {
+            e.preventDefault();
             router.open(item, e, itemProps.href, itemProps.routerOptions);
           }
 
@@ -165,6 +173,7 @@ export function useSelectableCollection(options: AriaSelectableCollectionOptions
         } else if (selectOnFocus && !isNonContiguousSelectionModifier(e)) {
           manager.replaceSelection(key);
         }
+        e.preventDefault();
       }
     };
 
@@ -178,7 +187,6 @@ export function useSelectableCollection(options: AriaSelectableCollectionOptions
             nextKey = delegate.getFirstKey?.(manager.focusedKey);
           }
           if (nextKey != null) {
-            e.preventDefault();
             navigateToKey(nextKey);
           }
         }
@@ -193,7 +201,6 @@ export function useSelectableCollection(options: AriaSelectableCollectionOptions
             nextKey = delegate.getLastKey?.(manager.focusedKey);
           }
           if (nextKey != null) {
-            e.preventDefault();
             navigateToKey(nextKey);
           }
         }
@@ -206,7 +213,6 @@ export function useSelectableCollection(options: AriaSelectableCollectionOptions
             nextKey = direction === 'rtl' ? delegate.getFirstKey?.(manager.focusedKey) : delegate.getLastKey?.(manager.focusedKey);
           }
           if (nextKey != null) {
-            e.preventDefault();
             navigateToKey(nextKey, direction === 'rtl' ? 'first' : 'last');
           }
         }
@@ -219,17 +225,20 @@ export function useSelectableCollection(options: AriaSelectableCollectionOptions
             nextKey = direction === 'rtl' ? delegate.getLastKey?.(manager.focusedKey) : delegate.getFirstKey?.(manager.focusedKey);
           }
           if (nextKey != null) {
-            e.preventDefault();
             navigateToKey(nextKey, direction === 'rtl' ? 'last' : 'first');
           }
         }
         break;
       }
       case 'Home':
+        if (e.altKey || (e.shiftKey && manager.selectionMode !== 'multiple') || (isAppleDevice() ? e.ctrlKey : e.metaKey)) {
+          return;
+        }
         if (delegate.getFirstKey) {
           if (manager.focusedKey === null && e.shiftKey) {
             return;
           }
+          e.stopPropagation();
           e.preventDefault();
           let firstKey: Key | null = delegate.getFirstKey(manager.focusedKey, isCtrlKeyPressed(e));
           manager.setFocusedKey(firstKey);
@@ -243,10 +252,14 @@ export function useSelectableCollection(options: AriaSelectableCollectionOptions
         }
         break;
       case 'End':
+        if (e.altKey || (e.shiftKey && manager.selectionMode !== 'multiple') || (isAppleDevice() ? e.ctrlKey : e.metaKey)) {
+          return;
+        }
         if (delegate.getLastKey) {
           if (manager.focusedKey === null && e.shiftKey) {
             return;
           }
+          e.stopPropagation();
           e.preventDefault();
           let lastKey = delegate.getLastKey(manager.focusedKey, isCtrlKeyPressed(e));
           manager.setFocusedKey(lastKey);
@@ -263,7 +276,6 @@ export function useSelectableCollection(options: AriaSelectableCollectionOptions
         if (delegate.getKeyPageBelow && manager.focusedKey != null) {
           let nextKey = delegate.getKeyPageBelow(manager.focusedKey);
           if (nextKey != null) {
-            e.preventDefault();
             navigateToKey(nextKey);
           }
         }
@@ -272,18 +284,24 @@ export function useSelectableCollection(options: AriaSelectableCollectionOptions
         if (delegate.getKeyPageAbove && manager.focusedKey != null) {
           let nextKey = delegate.getKeyPageAbove(manager.focusedKey);
           if (nextKey != null) {
-            e.preventDefault();
             navigateToKey(nextKey);
           }
         }
         break;
       case 'a':
+        if (e.altKey || e.shiftKey || (isAppleDevice() ? e.ctrlKey : e.metaKey)) {
+          return;
+        }
         if (isCtrlKeyPressed(e) && manager.selectionMode === 'multiple' && disallowSelectAll !== true) {
+          e.stopPropagation();
           e.preventDefault();
           manager.selectAll();
         }
         break;
       case 'Escape':
+        if (e.altKey || e.shiftKey || e.metaKey || e.ctrlKey) {
+          return;
+        }
         if (escapeKeyBehavior === 'clearSelection' && !disallowEmptySelection && manager.selectedKeys.size !== 0) {
           e.stopPropagation();
           e.preventDefault();
@@ -291,6 +309,9 @@ export function useSelectableCollection(options: AriaSelectableCollectionOptions
         }
         break;
       case 'Tab': {
+        if (e.altKey || e.metaKey || e.ctrlKey) {
+          return;
+        }
         if (!allowsTabNavigation) {
           // There may be elements that are "tabbable" inside a collection (e.g. in a grid cell).
           // However, collections should be treated as a single tab stop, with arrow key navigation internally.
diff --git a/packages/react-aria-components/test/ListBox.test.js b/packages/react-aria-components/test/ListBox.test.js
index 5cad37237cb..040a82bd6b8 100644
--- a/packages/react-aria-components/test/ListBox.test.js
+++ b/packages/react-aria-components/test/ListBox.test.js
@@ -2007,3 +2007,50 @@ describe('ListBox', () => {
     });
   }
 });
+
+describe('keyboard modifier keys', () => {
+  let user;
+  let platformMock;
+  beforeAll(() => {
+    user = userEvent.setup({delay: null, pointerMap});
+  });
+  // selectionMode: 'none', 'single', 'multiple'
+  // selectionBehavior: 'toggle', 'replace'
+  // platform: 'mac', 'windows'
+
+  // modifier key: 'alt', 'ctrl', 'meta', 'shift'
+  // key: 'arrow-up', 'arrow-down', 'arrow-left', 'arrow-right', 'home', 'end', 'page-up', 'page-down', 'enter', 'space', 'tab'
+  // expected behavior: 'navigate', 'select', 'toggle', 'replace'
+  describe('mac', () => {
+    beforeAll(() => {
+      platformMock = jest.spyOn(navigator, 'platform', 'get').mockImplementation(() => 'Mac');
+    });
+    afterAll(() => {
+      platformMock.mockRestore();
+    });
+    it('should not navigate when using unsupported modifier keys', async () => {
+      let {getByRole} = renderListbox({selectionMode: 'none'});
+      await user.tab();
+      let listbox = getByRole('listbox');
+      let options = within(listbox).getAllByRole('option');
+      await user.keyboard('{ArrowDown}');
+      expect(document.activeElement).toBe(options[1]);
+      await user.keyboard('{Meta>}{ArrowRight}{/Meta}');
+      expect(document.activeElement).toBe(options[1]);
+      await user.keyboard('{Meta>}{ArrowLeft}{/Meta}');
+      expect(document.activeElement).toBe(options[1]);
+      await user.keyboard('{Meta>}{ArrowDown}{/Meta}');
+      expect(document.activeElement).toBe(options[1]);
+      await user.keyboard('{Meta>}{ArrowUp}{/Meta}');
+      expect(document.activeElement).toBe(options[1]);
+      await user.keyboard('{Control>}{Home}{/Control}');
+      expect(document.activeElement).toBe(options[1]);
+      await user.keyboard('{Control>}{End}{/Control}');
+      expect(document.activeElement).toBe(options[1]);
+      await user.keyboard('{Meta>}{PageUp}{/Meta}');
+      expect(document.activeElement).toBe(options[1]);
+      await user.keyboard('{Meta>}{PageDown}{/Meta}');
+      expect(document.activeElement).toBe(options[1]);
+    });
+  });
+});
diff --git a/packages/react-aria-components/test/Tabs.test.js b/packages/react-aria-components/test/Tabs.test.js
index bc18c2d1ee7..fbeb3f2c2c3 100644
--- a/packages/react-aria-components/test/Tabs.test.js
+++ b/packages/react-aria-components/test/Tabs.test.js
@@ -288,6 +288,30 @@ describe('Tabs', () => {
     expect(document.activeElement).toBe(items[2]);
   });
 
+  it('should not navigate when using unsupported modifier keys', async () => {
+    let platformMock = jest.spyOn(navigator, 'platform', 'get').mockImplementation(() => 'Mac');
+    let {getAllByRole} = render(
+      <Tabs>
+        <TabList aria-label="Test">
+          <Tab id="a">A</Tab>
+          <Tab id="b" isDisabled>B</Tab>
+          <Tab id="c">C</Tab>
+        </TabList>
+        <TabPanel id="a">A</TabPanel>
+        <TabPanel id="b">B</TabPanel>
+        <TabPanel id="c">C</TabPanel>
+      </Tabs>
+    );
+    let items = getAllByRole('tab');
+    expect(items[1]).toHaveAttribute('aria-disabled', 'true');
+
+    await user.tab();
+    expect(document.activeElement).toBe(items[0]);
+    await user.keyboard('{Meta>}{ArrowRight}{/Meta}');
+    expect(document.activeElement).toBe(items[0]);
+    platformMock.mockRestore();
+  });
+
   it('finds the first non-disabled tab', async () => {
     let {getAllByRole} = render(
       <Tabs>