diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index cadac5c9f..0ed108cbd 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -122,7 +122,58 @@ jobs:
           CT2_USE_MKL: 1
         run: |
           ASAN_OPTIONS=detect_leaks=1:print_stats=1 tests/ctranslate2_test tests/data
-          
+
+  build-and-test-cpp-x86_64-thread_sanitizer:
+    runs-on: ubuntu-22.04
+    env:
+      CT2_VERBOSE: 1
+
+    steps:
+      - uses: actions/checkout@v4
+        with:
+          submodules: recursive
+
+      - name: Install Intel oneAPI
+        run: |
+          wget https://apt.repos.intel.com/intel-gpg-keys/GPG-PUB-KEY-INTEL-SW-PRODUCTS.PUB
+          sudo apt-key add *.PUB
+          sudo sh -c 'echo "deb https://apt.repos.intel.com/oneapi all main" > /etc/apt/sources.list.d/oneAPI.list'
+          sudo apt update
+
+      - name: Install MKL
+        env:
+          CT2_USE_MKL: 1
+          MKL_VERSION: 2023.0.0
+        run: |
+          sudo apt install -y intel-oneapi-mkl-devel-$MKL_VERSION
+
+      - name: Install Clang
+        run: |
+          sudo apt install -y clang  
+
+      - name: Configure with MKL and Clang
+        env:
+          CT2_USE_MKL: 1
+        run: |
+          cmake -DCMAKE_INSTALL_PREFIX=$PWD/install -DBUILD_TESTS=ON -DCMAKE_C_COMPILER=/usr/bin/clang -DCMAKE_CXX_COMPILER=/usr/bin/clang++ -DENABLE_THREAD_SANITIZER=ON -DCMAKE_BUILD_TYPE=Debug .
+
+      - name: Build
+        run: |
+          make -j $(nproc) install
+
+      - name: Download test data
+        working-directory: tests/data/models
+        run: |
+          wget https://opennmt-models.s3.amazonaws.com/pi_lm_step_5000.pt
+          wget https://opennmt-models.s3.amazonaws.com/transliteration-aren-all.tar.gz
+          tar xf transliteration-aren-all.tar.gz
+
+      - name: Test ThreadSanitizer
+        env:
+          CT2_USE_MKL: 1
+        run: |
+          TSAN_OPTIONS="ignore_noninstrumented_modules=1:halt_on_error=1" tests/ctranslate2_test tests/data
+
   build-and-test-cpp-arm64:
     runs-on: ${{ matrix.os }}
     env:
diff --git a/CMakeLists.txt b/CMakeLists.txt
index cf80e37b5..7334d4dc2 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -24,6 +24,7 @@ option(BUILD_SHARED_LIBS "Build shared libraries" ON)
 option(WITH_TENSOR_PARALLEL "Compile with NCCL and MPI backend" OFF)
 option(WITH_FLASH_ATTN "Compile with Flash Attention 2" OFF)
 option(ENABLE_ADDRESS_SANITIZER "ASAN" OFF)
+option(ENABLE_THREAD_SANITIZER "TSAN" OFF)
 
 MESSAGE(STATUS "Compiler Id: ${CMAKE_CXX_COMPILER_ID}")
 MESSAGE(STATUS "Compiler Version: ${CMAKE_CXX_COMPILER_VERSION}")
@@ -481,13 +482,20 @@ if (WITH_RUY)
   list(APPEND LIBRARIES ruy)
 endif()
 
+# sanitizers
 IF (ENABLE_ADDRESS_SANITIZER AND (CMAKE_BUILD_TYPE STREQUAL "Debug" OR CMAKE_BUILD_TYPE STREQUAL "DEBUG"))
-  MESSAGE (STATUS "ENABLE_ADDRESS_SANITIZER: ENABLED")
+  MESSAGE (STATUS "ENABLE_ADDRESS_SANITIZER: TRUE")
   set(ASAN_FLAGS " -fsanitize=address -fno-omit-frame-pointer -fno-optimize-sibling-calls -fno-common")
   string(APPEND CMAKE_C_FLAGS ${ASAN_FLAGS})
   string(APPEND CMAKE_CXX_FLAGS ${ASAN_FLAGS})
   add_link_options(-fsanitize=address)
-ELSEIF (ENABLE_ADDRESS_SANITIZER)
+ELSEIF (ENABLE_THREAD_SANITIZER AND (CMAKE_BUILD_TYPE STREQUAL "Debug" OR CMAKE_BUILD_TYPE STREQUAL "DEBUG"))
+  MESSAGE (STATUS "ENABLE_THREAD_SANITIZER: TRUE")
+  set(TSAN_FLAGS " -fsanitize=thread")
+  string(APPEND CMAKE_C_FLAGS ${TSAN_FLAGS})
+  string(APPEND CMAKE_CXX_FLAGS ${TSAN_FLAGS})
+  add_link_options(-fsanitize=thread)
+ELSEIF (ENABLE_ADDRESS_SANITIZER OR ENABLE_THREAD_SANITIZER)
   MESSAGE(FATAL_ERROR "SANITIZER requires Debug build type")
 ENDIF ()