diff --git a/CMakeLists.txt b/CMakeLists.txt
index bd72356f..6d1c7e77 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -101,6 +101,7 @@ kompute_option(KOMPUTE_OPT_ANDROID_BUILD "Enable android compilation flags requi
 kompute_option(KOMPUTE_OPT_DISABLE_VK_DEBUG_LAYERS "Explicitly disable debug layers even on debug." OFF)
 kompute_option(KOMPUTE_OPT_DISABLE_VULKAN_VERSION_CHECK "Whether to check if your driver supports the Vulkan Header version you are linking against. This might be useful in case you build shared on a different system than you run later." OFF)
 kompute_option(KOMPUTE_OPT_BUILD_SHADERS "Rebuilds all compute shaders during compilation and does not use the already precompiled versions. Requires glslangValidator to be installed on your system." OFF)
+kompute_option(KOMPUTE_OPT_THREAD_SAFE_COMPUTE_QUEUE "Enable manager-owned mutex protection around sequence queue submissions." OFF)
 
 # External components
 kompute_option(KOMPUTE_OPT_USE_BUILT_IN_SPDLOG "Use the built-in version of Spdlog. Requires 'KOMPUTE_OPT_USE_SPDLOG' to be set to ON in order to have any effect." ON)
diff --git a/src/Manager.cpp b/src/Manager.cpp
index b5facd0c..e5a56d0e 100644
--- a/src/Manager.cpp
+++ b/src/Manager.cpp
@@ -55,6 +55,10 @@ Manager::Manager(uint32_t physicalDeviceIndex,
 {
     this->mManageResources = true;
 
+#ifdef KOMPUTE_OPT_THREAD_SAFE_COMPUTE_QUEUE
+    this->mSequenceSubmitMutex = std::make_shared<std::mutex>();
+#endif
+
 // Make sure the logger is setup
 #if !KOMPUTE_OPT_LOG_LEVEL_DISABLED
     logger::setupLogger();
@@ -71,6 +75,10 @@ Manager::Manager(std::shared_ptr<vk::Instance> instance,
 {
     this->mManageResources = false;
 
+#ifdef KOMPUTE_OPT_THREAD_SAFE_COMPUTE_QUEUE
+    this->mSequenceSubmitMutex = std::make_shared<std::mutex>();
+#endif
+
     this->mInstance = instance;
     this->mPhysicalDevice = physicalDevice;
     this->mDevice = device;
@@ -495,12 +503,18 @@ Manager::sequence(uint32_t queueIndex, uint32_t totalTimestamps)
 {
     KP_LOG_DEBUG("Kompute Manager sequence() with queueIndex: {}", queueIndex);
 
+    std::shared_ptr<std::mutex> submitMutex = nullptr;
+#ifdef KOMPUTE_OPT_THREAD_SAFE_COMPUTE_QUEUE
+    submitMutex = this->mSequenceSubmitMutex;
+#endif
+
     std::shared_ptr<Sequence> sq{ new kp::Sequence(
-      this->mPhysicalDevice,
-      this->mDevice,
-      this->mComputeQueues[queueIndex],
-      this->mComputeQueueFamilyIndices[queueIndex],
-      totalTimestamps) };
+        this->mPhysicalDevice,
+        this->mDevice,
+        this->mComputeQueues[queueIndex],
+        this->mComputeQueueFamilyIndices[queueIndex],
+        totalTimestamps,
+        submitMutex) };
 
     if (this->mManageResources) {
         this->mManagedSequences.push_back(sq);
diff --git a/src/Sequence.cpp b/src/Sequence.cpp
index d8063e37..120f9c99 100644
--- a/src/Sequence.cpp
+++ b/src/Sequence.cpp
@@ -8,7 +8,8 @@ Sequence::Sequence(std::shared_ptr<vk::PhysicalDevice> physicalDevice,
                    std::shared_ptr<vk::Device> device,
                    std::shared_ptr<vk::Queue> computeQueue,
                    uint32_t queueIndex,
-                   uint32_t totalTimestamps) noexcept
+                   uint32_t totalTimestamps,
+                   std::shared_ptr<std::mutex> submitMutex) noexcept
 {
     KP_LOG_DEBUG("Kompute Sequence Constructor with existing device & queue");
 
@@ -17,6 +18,7 @@ Sequence::Sequence(std::shared_ptr<vk::PhysicalDevice> physicalDevice,
     this->mComputeQueue = computeQueue;
     this->mQueueIndex = queueIndex;
     this->mFence = this->mDevice->createFence(vk::FenceCreateInfo());
+    this->mSubmitMutex = submitMutex;
 
     this->createCommandPool();
     this->createCommandBuffer();
@@ -133,11 +135,22 @@ Sequence::evalAsync()
 
     this->mDevice->resetFences({ this->mFence });
 
-    this->mComputeQueue->submit(1, &submitInfo, this->mFence);
+    this->submitCommandBuffer(submitInfo);
 
     return shared_from_this();
 }
 
+void
+Sequence::submitCommandBuffer(const vk::SubmitInfo& submitInfo)
+{
+    if (this->mSubmitMutex) {
+        std::lock_guard<std::mutex> submitLock(*this->mSubmitMutex);
+        this->mComputeQueue->submit(1, &submitInfo, this->mFence);
+    } else {
+        this->mComputeQueue->submit(1, &submitInfo, this->mFence);
+    }
+}
+
 std::shared_ptr<Sequence>
 Sequence::evalAsync(std::shared_ptr<OpBase> op)
 {
diff --git a/src/include/kompute/Manager.hpp b/src/include/kompute/Manager.hpp
index cc02df80..d76b10d0 100644
--- a/src/include/kompute/Manager.hpp
+++ b/src/include/kompute/Manager.hpp
@@ -7,6 +7,10 @@
 #include "kompute/Sequence.hpp"
 #include "logger/Logger.hpp"
 
+#ifdef KOMPUTE_OPT_THREAD_SAFE_COMPUTE_QUEUE
+#include <mutex>
+#endif
+
 #define KP_DEFAULT_SESSION "DEFAULT"
 
 namespace kp {
@@ -546,6 +550,10 @@ class Manager
     std::vector<uint32_t> mComputeQueueFamilyIndices;
     std::vector<std::shared_ptr<vk::Queue>> mComputeQueues;
 
+  #ifdef KOMPUTE_OPT_THREAD_SAFE_COMPUTE_QUEUE
+    std::shared_ptr<std::mutex> mSequenceSubmitMutex = nullptr;
+  #endif
+
     bool mManageResources = false;
 
 #ifndef KOMPUTE_DISABLE_VK_DEBUG_LAYERS
diff --git a/src/include/kompute/Sequence.hpp b/src/include/kompute/Sequence.hpp
index 169321c7..bea23fc2 100644
--- a/src/include/kompute/Sequence.hpp
+++ b/src/include/kompute/Sequence.hpp
@@ -5,6 +5,8 @@
 
 #include "kompute/operations/OpAlgoDispatch.hpp"
 #include "kompute/operations/OpBase.hpp"
+#include <mutex>
+#include <functional>
 
 namespace kp {
 
@@ -28,7 +30,8 @@ class Sequence : public std::enable_shared_from_this<Sequence>
              std::shared_ptr<vk::Device> device,
              std::shared_ptr<vk::Queue> computeQueue,
              uint32_t queueIndex,
-             uint32_t totalTimestamps = 0) noexcept;
+             uint32_t totalTimestamps = 0,
+             std::shared_ptr<std::mutex> submitMutex = nullptr) noexcept;
 
     /**
      * @brief Make Sequence uncopyable
@@ -293,11 +296,20 @@ class Sequence : public std::enable_shared_from_this<Sequence>
     vk::Fence mFence;
     std::vector<std::shared_ptr<OpBase>> mOperations{};
     std::shared_ptr<vk::QueryPool> timestampQueryPool = nullptr;
+    std::shared_ptr<std::mutex> mSubmitMutex = nullptr;
 
     // State
     bool mRecording = false;
     bool mIsRunning = false;
 
+    /**
+     * Submits the command buffer to the compute queue, acquiring the submit
+     * mutex beforehand if one was provided.
+     *
+     * @param submitInfo The Vulkan submit info to pass to the queue.
+     */
+    void submitCommandBuffer(const vk::SubmitInfo& submitInfo);
+
   private:
     // Create functions
     void createCommandPool();